RAF Typhoon fighter aircraft have operated alongside French warplanes in a combined operation on an subterranean weapons facility in Syrian territory employed by the IS group, according to the UK Ministry of Defence.
The location, located using surveillance, was thought to be storing arms and explosives, the statement said, and was located in mountainous terrain just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets used Paveway IV guided bombs to strike a several access tunnels leading to the site... initial indications suggest the target was engaged successfully," the MoD said.
There was no sign of any harm to civilians in the strike on Saturday evening and every plane involved returned safely, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
Daesh - referred to as ISIS - established jihadist rule over large swathes of Iraq and Syria prior to its 2019 collapse.
"This action demonstrates the UK's leading role, and determination to work closely with our allies, to eliminate any revival of IS and their harmful and extremist ideologies in the Middle East," Britain's Defence Chief John Healey stated.
UK warplanes have carried out patrols over Syrian airspace to "prevent any attempted comeback" of the group subsequent to its routing at the climactic battle in Baghuz in 2019, the authorities noted.
"I want to thank every member of the UK armed forces who took part in this operation for their skill and their valour," Healey said. "Including them were thousands of British personnel deployed over the festive period. This mission, to remove militants who pose a risk to our safety, shows how our armed forces are always on standby, throughout the year, keeping Britain secure domestically and strong abroad."
Last December, the United States armed forces executed what it termed a "large-scale strike" on Islamic State objectives in Syria, after an attack claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The United Nations reports IS still maintains an estimated 5,000 to 7,000 militants in Iraq and Syria.
